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Article
May 1937

SIMMONDS' DISEASE (ANTERIOR HYPOPHYSIAL INSUFFICIENCY): REPORT OF TWO CASES WITH AUTOPSY

Author Affiliations

CLEVELAND

From the Laboratory of Pathology, the Cleveland City Hospital, and the Department of Pathology, Western Reserve University.

Arch Intern Med (Chic). 1937;59(5):865-882. doi:10.1001/archinte.1937.00170210108008
Abstract

Because of the current interest in diseases of the endocrine glands and because of the comparative sparsity of reports of cases of Simmonds' disease with autopsy, the following cases are placed on record. There is included also a comparison of some of the effects of the glandular deficiency of Simmonds' disease and of the glandular hyperfunction of acromegaly.

REPORT OF CASES 

Case 1.  —A 51 year old housewife was admitted to the Cleveland City Hospital on April 10, 1935, in coma.

Clinical History.  —The clinical history was obtained from the records of the University Hospital Dispensary, where the patient was first seen on June 8, 1933. She complained then only of pain and stiffness of the knees, which were worse after disuse and improved with exercise. These symptoms began three years previously, after six months of convalescence from a difficult delivery. The menses, which had been normal, had stopped, and

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