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July 1937


Arch Intern Med (Chic). 1937;60(1):167-175. doi:10.1001/archinte.1937.00180010172013

EXPERIMENTAL GLOMERULONEPHRITIS  The past year has been characterized by marked progress in attempts to produce glomerulonephritis experimentally. These attempts have been recently reviewed by Masugi,1 who was one of the earliest to achieve experimental glomerulonephritis; by Ahlström,2 and by Smadel.3 All of these workers have utilized cytotoxic serum in its production.Ahlström2 began by investigating the action of Dick toxin, finding that it had a weak nephrotoxic action and produced only a few focal degenerative changes when injected into the renal arteries of normal rabbits or of rabbits which had been previously sensitized to Dick toxin.Ahlström found also that when serum was injected into the renal arteries of sensitized animals most of them showed only perivascular cell infiltrates, frequently localized about the afferent glomerular artery, in which occasionally hyaline thrombi were observed and in some instances slight glomerular changes as well. When, however, animals which

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