Since ammonia appears to be elaborated by the renal tubules, the activity of its production might, if looked at from a proper theoretical point of view, throw light on the functional state of the tubular division of the renal parenchyma; an altered functional state with nephritis might be reflected in a corresponding alteration of the activity of production of ammonia.
The suggestion for the present study came with the development of a new view concerning the mechanism which results in the production of ammonia by the kidney.1 According to this view, the production of ammonia by the renal tubules is stimulated by and serves to neutralize the acid residue which remains to flow through the tubules after resorption of the alkaline threshold moiety from the glomerular filtrate.2 In contrast to this theory is the classic concept, which assumes that production of ammonia responds to the requirements of the
BRIGGS AP. FUNCTIONAL ACTIVITY OF RENAL EPITHELIUM IN CERTAIN TYPES OF NEPHRITIS: AS INDICATED BY SECRETION OF AMMONIA. Arch Intern Med (Chic). 1937;60(2):193–202. doi:10.1001/archinte.1937.00180020017002
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