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August 1937


Author Affiliations


From the Department of Pathology and the Department of Surgery, the University of Illinois College of Medicine.

Arch Intern Med (Chic). 1937;60(2):251-263. doi:10.1001/archinte.1937.00180020075006

The possibility of supplying the nitrogen requirements of the body parenterally led us to investigate the effect of protein split products given by this route. For many years reports have appeared in the literature on various phases of the phenomenon which has been designated "peptone shock." These have included elaborate chemical studies and physiologic observations made after the parenteral and oral administration of certain protein split products. This work has all been carried out with crude products of protein digestion. In consequence the results obtained have been variable and often contradictory.

REVIEW OF THE LITERATURE  In 1913 Henriques and Andersen1 described experiments in which they maintained goats in positive nitrogen balance by means of intravenous injections. The authors achieved this by administering a solution containing completely digested (trypsin-erepsin) meat, dextrose, sodium acetate, sodium chloride, potassium chloride, calcium chloride and magnesium chloride by continuous intravenous drip. They concluded that protein