The influence of copper on the formation of hemoglobin is a problem which has not been completely solved, and the literature abounds in conflicting reports on the subject. Elvehjem1 has recently summarized the work on the biologic significance of copper, and the reader is referred to this paper for a comprehensive review and bibliography. It has been found that in the experimental nutritional anemia of animals neither iron nor copper alone is effective in producing regeneration of hemoglobin, but when iron is given in combination with a small amount of copper a rapid increase in the hemoglobin content of the blood ensues. The work of Whipple2 on experimental hemorrhagic anemia in dogs has not entirely confirmed these results. He found that in certain instances a combination of iron and copper was more beneficial than iron alone but that this was not consistently true. It is possible that a
BARER AP, FOWLER WM. INFLUENCE OF COPPER AND A LIVER FRACTION ON RETENTION OF IRON. Arch Intern Med (Chic). 1937;60(3):474–481. doi:10.1001/archinte.1937.00180030091009
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