Parenterally administered iron has been used for many years in the treatment of anemia. Stockman,1 in 1893, reported on the efficacy of this mode of administration and quoted many previous investigators who had found it to be of value, but from his own experience he concluded that a more rapid increase in the hemoglobin content could be obtained by oral administration. He stated, however, that the therapeutic activity of iron when given by this route was evidence that it was actually absorbed and utilized, a point which was being questioned at that time. This method of administration has been used by Witts,2 by Barlow3 and Bullock4 in the anemia of tuberculosis and by Morse5 in the anemia of infants, as well as by numerous other investigators. All have recognized the fact that the amount of iron administered parenterally must be small because of its toxicity.
FOWLER WM, BARER AP. RETENTION AND UTILIZATION OF PARENTERALLY ADMINISTERED IRON. Arch Intern Med (Chic). 1937;60(6):967–973. doi:10.1001/archinte.1937.00180060020002