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January 1938


Author Affiliations

Fellow in Surgery, the Mayo Foundation; ROCHESTER, MINN.

From the Division of Experimental Medicine, the Mayo Foundation.

Arch Intern Med (Chic). 1938;61(1):119-128. doi:10.1001/archinte.1938.00180070124009

The administration of cinchophen is an effective method for producing chronic peptic ulcer in dogs. It may be said that the method is uniformly successful, depending on three conditions; they are: (1) sufficient cinchophen administered over (2) a sufficient period to dogs which (3) take food every day. Surgical alteration of the gastrointestinal tract is not necessary for the production of this type of ulcer. The chronic ulcer is usually single and appears in the same region of the stomach in which it is noted in man, namely, on the posterior wall near the lesser curvature and between the incisura and the pylorus. Infrequently an ulcer is seen on the anterior wall, and none has been noted on the greater curvature. Duodenal ulcer occurs rarely and has been noted only in association with a larger gastric ulcer. The ulcer begins to heal with the discontinuation of administration of cinchophen and