In a previous paper one of us1 presented certain observations indicating that the pain of diabetic neuritis was relieved temporarily by the oral administration of sodium chloride in amounts ranging from 15 to 90 Gm. daily over periods of two to four weeks with interruptions of ten to fourteen days. It appeared likely that the relief thus obtained was due to a vasodilating effect of the sodium chloride. The present study was undertaken primarily for the purpose of studying the effect of this salt on a larger series of diabetic patients complaining of pain who had not been relieved by the usual diabetic management.
Thirteen patients with pain of either neuritic or vascular origin were studied. For the purpose of study the patients were divided into three groups: first, a group of seven patients in whom definite neurologic signs were found, consisting of hyporeflexia, areflexia and sensory changes;
SANDSTEAD HR, BEAMS AJ. RELIEF OF DIABETIC PAIN OF NEUROCIRCULATORY ORIGIN BY ORAL ADMINISTRATION OF SODIUM CHLORIDE. Arch Intern Med (Chic). 1938;61(3):371–380. doi:10.1001/archinte.1938.00020030001001