Many data have been accumulated on the iron requirements of normal and of pathologic subjects,1 as well as on the amount of iron which is retained and utilized by patients with anemia of various types.2 We have shown that patients with hypochromic anemia retain a large amount of iron but utilize only a relatively small percentage of that retained2a and that the absence of hydrochloric acid in the gastric juice interferes with the retention of dietary iron but has no effect when large doses of medicinal iron are administered.3 We have also shown that the degree of anemia which is present has no appreciable effect on the amount of iron retained.3 The effect of copper and of a liver fraction given in combination with the iron has also been studied,4 as well as the results obtained with variable amounts of iron.5 We wish
FOWLER WM, BARER AP. IRON RETENTION IN PERNICIOUS ANEMIA, LEAD POISONING AND MYXEDEMA. Arch Intern Med (Chic). 1938;61(3):401–407. doi:10.1001/archinte.1938.00020030031003
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