At the meeting of the American Medical Association in Milwaukee in 1933 Dr. C. H. Watkins, of the Mayo Clinic, announced that a strained preparation of yellow bone marrow had been beneficial in cases of granulocytopenia. After the use of the yellow marrow, monocytosis occurred and was rapidly followed by an increase in the number of polymorphonuclear neutrophils. This reaction occurred generally within twenty-four to forty-eight hours after ingestion of the marrow.1 A report of this work has not yet been published by Dr. Watkins.
Shortly after this announcement Dr. M. J. Flipse, of Miami, Fla., successfully used yellow bone marrow for a series of patients suffering from granulocytopenia.2 This preparation is extremely unpalatable and has the further disadvantage that it must be taken in very large doses (60 to 120 Gm. or more daily), in some cases large enough to interfere with normal metabolism. Dr. Flipse expressed
C. M. MARBERG, HAROLD O. WILES. GRANULOCYTOPOIETIC FRACTION OF YELLOW BONE MARROW. Arch Intern Med (Chic). 1938;61(3):408–429. doi:10.1001/archinte.1938.00020030038004