On April 1, 1929, a patient came to the Mayo Clinic complaining of chronic infectious (atrophic, rheumatoid) arthritis of four years' duration. He stated that a week previously, no medicine having been taken, painless jaundice suddenly developed. He said that on March 25, the day after he noted the jaundice, the pain and swelling in his joints began to diminish. When the patient was examined at the clinic the joints were symptomless; this complete symptomatic remission lasted five months with respect to the feet and eight months with respect to the hands. The phenomenon so impressed the patient that when he returned to the clinic two years later (May 1931), with moderately active arthritis, he reminded me that the only time his joints ever had been entirely free from pain was during and just after the jaundice. In the meantime, three other patients who had come under my observation had
HENCH PS. EFFECT OF JAUNDICE ON CHRONIC INFECTIOUS (ATROPHIC) ARTHRITIS AND ON PRIMARY FIBROSITIS: FURTHER OBSERVATIONS; ATTEMPTS TO REPRODUCE THE PHENOMENON. Arch Intern Med (Chic). 1938;61(3):451–480. doi:10.1001/archinte.1938.00020030081006
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