The first reference to the serologic diagnosis of amebiasis was made by Izar,1 in 1914. He experimented with complement fixation, the technic on which the Wassermann reaction for the diagnosis of syphilis is based. While sporadic studies were subsequently made, it remained for Craig2 (1927) to place this test on a relatively practical basis by improving the preparation of the antigen and standardizing the technic. Later attempts to improve the Craig test resulted in minor changes by Sherwood and Heathman3 (1932), Weiss and Arnold4 (1934) and Tsuchiya5 (1934). Each of these workers or pair of workers with a different modification of the test has corroborated, in the main, Craig's contention of the specificity of complement fixation in the diagnosis of amebiasis. Details of the history and development of this procedure have been treated adequately in Craig's6 excellent monograph entitled "Amebiasis and Amebic Dysentery" (1934).
Interest in amebiasis has greatly
PAULSON M, ANDREWS J. COMPLEMENT FIXATION IN AMEBIASIS: A COMPARATIVE EVALUATION IN CLINICAL PRACTICE. Arch Intern Med (Chic). 1938;61(4):562–578. doi:10.1001/archinte.1938.00180090042004
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