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Article
April 1938

HYPERINSULINISM AND CEREBRAL CHANGES: REPORT OF A CASE DUE TO AN ISLET CELL ADENOMA OF THE PANCREAS

Author Affiliations

ANN ARBOR, MICH.; YPSILANTI, MICH.

From the Laboratory of the Neuropsychiatric Institute, University of Michigan, Dr. Raymond W. Waggoner, director, and the Ypsilanti State Hospital, Dr. George F. Inch, superintendent.

Arch Intern Med (Chic). 1938;61(4):579-599. doi:10.1001/archinte.1938.00180090059005
Abstract

In insulin hypoglycemia, or hyperinsulinism, whether spontaneous or induced, the manner in which the nervous system is affected is of primary interest. This has been investigated (1) in "insulin shock" of patients suffering from diabetes, (2) in spontaneous hypoglycemia due to neoplasm or to hypertrophy or functional oversecretion of the islands of Langerhans and (3) under experimental conditions. We wish to report a case of spontaneous hypoglycemia due to an adenoma of the islands of Langerhans. On the basis of our study of this case and a survey of the literature, an attempt will be made to correlate the clinical, laboratory and anatomic data on this disorder from the pathogenic standpoint.

REPORT OF CASE 

History.  —A. P., a married woman aged 30, was admitted to the Ypsilanti State Hospital on March 16, 1936. The family history and the patient's past history were essentially unimportant. She had been in good health

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