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May 1938


Arch Intern Med (Chic). 1938;61(5):762-773. doi:10.1001/archinte.1938.00180100072008

The clinical and pathologic aspects of porphyria were extensively reviewed by Mason, Courville and Ziskind1 in 1933. In the German literature the chemistry of porphyria has recently received considerable attention.2 In the American literature recent papers by Dobriner and his associates,3 Watson4 and Watson and Clarke5 have added important new data. The recent monograph by Waldenström6 has clarified the diagnostic criteria, the familial occurrence and much of the symptomatology of acute porphyria. The first two papers of the present series of studies7 have further introduced the basic chemical nature of the porphyrins and have presented evidence that porphyria may be a persistence of fetal pyrrole metabolism. For these reasons it is not considered necessary in this paper to go deeply into either the clinical or the chemical aspects that have been dealt with in the literature.

The present report of a case concerns what is commonly

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