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Article
May 1938

GASTRIC SECRETION IN MAN: OBSERVATIONS ON THE EFFECTS OF REPEATED INJECTIONS OF HISTAMINE AND ON TRANSIENT ACHLORHYDRIA

Arch Intern Med (Chic). 1938;61(5):774-780. doi:10.1001/archinte.1938.00180100084009
Abstract

The following report is based on studies carried out on a trained subject for four and a half years. The subject was originally selected to serve as the source of gastric juice for patients with pernicious anemia. Because of the fact that he was receiving repeated injections of histamine, we decided to study his gastric secretion. At first attention was paid only to the volume and the acidity; later, determinations of pepsin and chloride were included.

F. F., aged 49 years, a foreman of a railroad gang, entered the Cincinnati General Hospital, in February 1931, with paralysis of the extremities following ingestion of adulterated Jamaica ginger. His past history was unimportant except for chronic alcoholism. He had been surprisingly free from digestive disturbances. The general physical examination revealed only evidence of peripheral neuritis and of some involvement of the pyramidal tracts. The blood count, urinalysis and stool analysis gave normal

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