A considerable number of favorable reports on the clinical use of protamine zinc insulin in the treatment of diabetes mellitus have appeared in the literature. The articles of Joslin and his co-workers,1 Rabinowitch and his co-workers,2 Wilder3 and others may be cited as examples. In view of these reports there can be no question regarding the more prolonged action of protamine insulin as compared with that of insulin hydrochloride. It is also obvious that with constant proper laboratory supervision, it is possible to treat patients with diabetes mellitus satisfactorily with the newer forms of insulin and usually with a decrease both in the number of doses and in the quantity of insulin administered. Stress thus far has been on the favorable results and the advantages to be gained from a more uniform regulation of the level of blood sugar. Relatively little has been said of the difficulties
NEUHOFF F, RABINOVITCH S. PROTAMINE ZINC INSULIN: CLINICAL OBSERVATIONS AND COMPARATIVE ANALYSIS OF BLOOD SUGAR CURVES OBTAINED WITH USE OF PROTAMINE ZINC INSULIN AND WITH REGULAR INSULIN. Arch Intern Med (Chic). 1938;62(3):447–460. doi:10.1001/archinte.1938.00180140094008
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