Since the initial publication in 1927 by Weber and myself,1 describing an increase in the "guanidine" content of the blood of certain patients with arterial hypertension, a fairly extensive literature has grown up on this subject. In our first publication1 we submitted data on 21 patients with hypertension, pointing out at that time that 7 of these patients, with an increase in the "guanidine" content of the blood, showed nitrogen retention, that 11 patients showed no nitrogen retention and that 3 patients showed no increase in the "guanidine" content. In a further report published in the same year2 readings were presented for 35 patients who showed no nitrogen retention and for 5 patients who showed nitrogen retention. Twelve patients with arterial hypertension showed no increase in the "guanidine" content of the blood. One patient with arterial hypertension and nitrogen retention showed no increase in the "guanidine" content.
MAJOR RH. BLOOD "GUANIDINE" IN ARTERIAL HYPERTENSION: A REVIEW OF EIGHT HUNDRED CASES. Arch Intern Med (Chic). 1938;62(6):946–948. doi:10.1001/archinte.1938.00180170046004
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