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March 1939

Hypervitaminosis D, belyst gennem kvantitative overdoseringsforsøg.

Arch Intern Med (Chic). 1939;63(3):606-607. doi:10.1001/archinte.1939.00180200175018

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This dissertation is concerned with the question of whether the poisoning produced by excessive doses of preparations of vitamin D is true hypervitaminosis or merely poisoning due to substances difficult to separate from the vitamin. The author is convinced that he dealt with true hypervitaminosis D in his experiments because preparations from three independent sources, when used on mice and rats, gave the following results: No qualitative difference was found in the symptoms produced by the three commercial preparations as compared with those produced by purified vitamin D. Quantitative comparison showed the toxicity to be proportional to the vitamin content, within the limits of experimental error. Doses which were harmless when given daily over short periods sometimes caused typical symptoms of hypervitaminosis if continued for longer periods, but sufficiently small doses, of 1,400 to 1,500 U. S. P. units per day, were continued for half a year without cumulative effects.

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