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This dissertation contains a review of the subject of vitamin E and a presentation of the author's own experiments on the rat. The sterility caused by lack of vitamin E affects not only the female but the male. In the latter the gradual testicular degeneration was followed in great detail up to four hundred and sixty days after institution of the deficient diet. The earliest changes were in the seminiferous elements, but later the interstitial tissue also suffered extreme atrophy. The degeneration was never uniform throughout a testicle; even in a maximally deteriorated organ a few well preserved seminal tubules persisted. While some of these changes were nonspecific, others seemed to be diagnostic of lack of vitamin E and therefore possibly of use in the development of methods of assay. For any one who may undertake research on the antisterility vitamin, this book, with its excellent photomicrographs and its wealth
Undersøgelser over testis histopathologi ved E-avitaminose: En eksperimentel-morphologisk studie.. Arch Intern Med (Chic). 1939;63(3):608. doi:10.1001/archinte.1939.00180200177022
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