Two nonrelated ovarian tumors associated with masculinization are now described, the arrhenoblastoma and a large cell type variously called hypernephroma, hypernephroid and luteoma. The reason for the variety of names for the latter growth is the imperfect knowledge of its histogenesis, some authors favoring its origin from an adrenal rest and others from lutein elements. The first report to appear in the literature was that of Bovin.1 Glynn2 in 1917 criticized inclusion of the tumor among ovarian growths, on the ground that it lay in the broad ligament and not primarily in the ovary.
Other reports of growths at first included in this group but later discarded followed. Thus Tuffier3 reported a case in which the diagnosis was primary adrenal tumor with metastasis to the ovary, while Cosacesco and his associates4 classified the lesion as lutéinome. However, the presence of large bilateral adrenal masses as well
ROTTINO A, MCGRATH JF. MASCULINOVOBLASTOMAPRIMARY MASCULINIZING TUMOR OF THE OVARY ( SO-CALLED LARGE CELL VARIETY—HYPERNEPHROID—LUTEOMA ). Arch Intern Med (Chic). 1939;63(4):686–710. doi:10.1001/archinte.1939.00180210079006
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