The variable values for serum phosphatase in cases of hepatic disease have never been satisfactorily explained. Experimental work by previous investigators has not led to results that would clarify the interpretation of the serum phosphatase level in clinical hepatic and biliary disorders. Both clinically and experimentally, serum phosphatase rises in cases of extrahepatic biliary obstruction. The variable results obtained clinically in cases of hepatic disease led us to investigate the influence of the liver on the serum phosphatase by attempting to correlate the underlying pathologic picture in the liver with the resultant value for serum phosphatase.
PROCEDURES AND RESULTS
All the experimental procedures were carried out under anesthesia induced by intravenous administration of pentobarbital sodium and under aseptic technic. In experiment 1, 3 dogs were used, 2 male and 1 female, each weighing approximately 30 pounds (13.6 Kg.). They were observed for ten days to establish the normal values for
SCHIFFMANN A, WINKELMAN L. INFLUENCE OF THE LIVER ON SERUM PHOSPHATASE. Arch Intern Med (Chic). 1939;63(5):919–929. doi:10.1001/archinte.1939.00180220109010
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