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June 1939


Arch Intern Med (Chic). 1939;63(6):1030-1047. doi:10.1001/archinte.1939.00180230015002

A gastric antacid is a chemical substance introduced into the stomach for the purpose of lowering the hydrogen ion concentration, or acidity, of the gastric contents. Such antacids are in common use in medical practice, mostly in the treatment of peptic ulcer, and in addition they are employed extensively in self medication by those who have recognized the efficacy of sodium bicarbonate in the relief of several types of gastric distress. Of the host of substances which are capable of neutralizing acid, only a few are adaptable to use as gastric antacids, and not more than a dozen have received general attention in therapeutic practice.

Unexpected difficulties are often encountered in the use of antacids to lower gastric acidity, because no antacid has yet been found which will simply neutralize acid without exhibiting additional pharmacologic action. These side actions usually have been objectionable rather than desirable. Under these circumstances it