This paper presents biochemical and clinical studies on patients receiving alkali therapy for peptic ulcer, as well as an analysis of the clinical records of 28 patients in whom alkalosis developed during treatment for ulcer.
Sippy1 introduced the practice of using large daily doses of alkali powders for the treatment of peptic ulcer in 1915. He observed toxic symptoms in some of his patients (Gatewood and associates2), In 1923 Hardt and Rivers3 published the first detailed account of alkali intoxication arising during the course of the Sippy treatment. They named the condition "alkalosis." Since that time cases of alkalosis have been reported with increasing frequency, so that the condition is now recognized as an important complication of the treatment of peptic ulcer (Hurst and Stewart4; Jordan and Kiefer5; Cooke6; Berger and Binger7; Oakley,8 and others). In the majority of patients who receive the Sippy type of treatment