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June 1939

Studies on Proteinuria "Albuminuria."

Arch Intern Med (Chic). 1939;63(6):1234-1235. doi:10.1001/archinte.1939.00180230219015

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The monograph is divided into four sections. In the first section the historical aspects of proteinuria are discussed, and special reference is made to the various mechanisms which produce it.

The second section describes the author's investigation of creatinine clearance as a measure of glomerular filtration. He believes that there is at present sufficient evidence that a close parallelism between the two exists but that there is not conclusive proof of it. An account is given of the special works throwing light on this subject.

The technic employed in the investigative work is explained in part 3. The author found that the total excretion of protein and albumin and thus of globulin, varies with the creatinine clearance. He points out that during protracted periods of proteinuria small quantities of proteins will make their way into the tubules, where they will be stored. In this way he explains the histogenesis of

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