In recent years clinical hematologists have devoted considerable attention to the cytologic structure of bone marrow removed at biopsy. Published accounts of their experience vary greatly in enthusiasm and in detail. Sufficient controversy surrounds the entire subject to justify a report of our experience at the University of Chicago Clinics and in the "Medicine A" service of St. Luke's Hospital. No attempt will be made to review or summarize the entire literature, and the papers referred to are those that amplify, controvert or illustrate our own opinions.
Marrow for study has been obtained chiefly from the tibia and the sternum; the latter source was most frequently chosen. Peabody1 and Nordenson,2 as well as others, have shown that the functioning marrow removed from different bones tends to be similar. In fact, the prime justification for selecting any single region from which to take biopsy material is the assumption that
KANDEL EV, LeROY GV. LIMITATIONS OF BIOPSY OF STERNAL MARROW. Arch Intern Med (Chic). 1939;64(1):121–135. doi:10.1001/archinte.1939.00190010131011
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