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August 1939


Author Affiliations


From the Department of Neurology, Graduate School of Medicine, University of Pennsylvania, and the Graduate Hospital.

Arch Intern Med (Chic). 1939;64(2):330-335. doi:10.1001/archinte.1939.00190020116009

The neuromuscular syndrome named myasthenia gravis has been recognized since its description by Willis1 in 1685. Since that time many hypotheses have been presented in the literature, but it must be admitted that as yet the essential cause or causes of myasthenia gravis are unknown. This communication is offered as a record of some empiric data concerned with the relation of the uncommon condition myasthenia gravis to the common syndrome of hyperthyroidism. A case is reported in which the two conditions appeared concurrently and in which the one seemed to inhibit or antagonize the other. Observations on a case of myasthenia gravis in which hyperthyroidism was artificially produced are given, together with a review of the literature.

REPORT OF A CASE  M. B., a woman aged 20, was first seen in June 1936. At that time she stated that she had generally been in excellent health until the middle