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Article
September 1939

EXPERIMENTAL RENAL INSUFFICIENCY PRODUCED BY PARTIAL NEPHRECTOMYXI. DIETS CONTAINING DRIED EXTRACTED LIVER

Arch Intern Med (Chic). 1939;64(3):513-525. doi:10.1001/archinte.1939.00190030106008
Abstract

The effect of feeding diets containing varying percentages of dried whole liver to intact, unilaterally nephrectomized and partially nephrectomized rats has been presented.1 In order to study the effect of removing the water-soluble extracts, dried extracted liver was fed to a similar group of animals. This investigation is concerned with the effect of diets containing increasing amounts of dried extracted liver on the weight of the kidney and of the heart, the blood pressure, the renal function and the relation of the concentration of urea in the blood and that in the urine of intact, unilaterally nephrectomized and partially nephrectomized rats.

EXPERIMENTAL METHODS  White rats, raised in the Laboratory of Physiological Chemistry of the University of Virginia, were maintained on a stock diet until they were between 60 and 70 days old, when unilateral nephrectomy or subtotal nephrectomy was performed. The details of the operative procedure and the care of

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