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September 1939

Diabetes Insipidus and the Neuro-Hormonal Control of Water Balance: A Contribution to the Structure and Function of the Hypothalamico Hypophyseal System.

Arch Intern Med (Chic). 1939;64(3):660. doi:10.1001/archinte.1939.00190030253019

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This monograph is concerned with the nervous and hormonal factors involved in the regulation of water balance and especially with the great increase in water exchange which characterizes the disease known as diabetes insipidus. The investigations were carried out in the Institute of Neurology of Northwestern University Medical School during the past six years. Although most of the facts presented have been published by the authors in various periodicals, it is highly pleasing to find them correlated and collected into one volume.

The principal method of study was the production of discrete lesions in various parts of the hypothalamus with the Horsley-Clarke stereotaxic instrument. Diabetes insipidus was produced in 85 cats and 2 monkeys. Among the final conclusions of the investigators are that the neural lobe of the hypophysis is an endocrine gland which plays an antidiuretic role in renal water balance and that diabetes insipidus is essentially a hypophysial

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