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Article
October 1939

MULTIPLE MYELOMAASSOCIATED WITH NODULAR DEPOSITS OF AMYLOID IN THE MUSCLES AND JOINTS AND WITH BENCE JONES PROTEINURIA

Arch Intern Med (Chic). 1939;64(4):820-833. doi:10.1001/archinte.1939.00190040161011
Abstract

The occurrence of typical and atypical amyloidosis associated with multiple myeloma is now well recognized.1 Atkinson2 in a review of 643 recorded cases of multiple myeloma found amyloid reported in 40, or an incidence of about 7 per cent. Unusual amyloid tumor formation and localization are cited by Helly,3 Randall,4 Glaus5 and Askanazy.6 The cases of multiple myeloma in which amyloidosis is atypical in its distribution or type are considered in this paper. In them, besides the underlying myeloma, there are amyloid masses in varying number and size distributed throughout the body. In certain cases the amyloid is found particularly in the voluntary musculature and in the joints, so that the clinical picture closely resembles that of rheumatoid arthritis. A survey of the literature reveals that there have been only 11 recorded cases of this type. It will be noted from the table that those first reported in the American

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