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October 1939

On the Stability of Transfused Erythrocytes.

Arch Intern Med (Chic). 1939;64(4):889. doi:10.1001/archinte.1939.00190040230015

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The estimations of the duration of life of the erythrocyte vary—with the author and the method of approach employed—from fifteen to two hundred days. Heretofore, practically all methods had to be limited to indirect procedures. The finding of the existence of blood groups M and N (Landsteiner and Levine, 1927) made possible the direct identification of transfused compatible red blood cells. The author found the average time for existence of erythrocytes after transfusion of 500 cc. of blood to the seventy-five and one-half days by microscopic evidence of heteroagglutination and fifty-four and one-half days by macroscopic evidence. The results of more than one hundred transfusions could be traced until after the disappearance of all the cells of the donor in 12 cases only. Four additional patients were traced forty-two to seventy-six days after the transfusion, at which time transfused erythrocytes were still present. Eight patients with secondary types of anemia,

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