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Article
November 1939

DELETERIOUS EFFECTS OF EXPERIMENTAL PROTAMINE INSULIN SHOCK

Arch Intern Med (Chic). 1939;64(5):907-912. doi:10.1001/archinte.1939.00190050013002
Abstract

The effects of hypoglycemia of long duration on the various tissues and on the organism as a whole are of fundamental importance. On the immediate practical side, the possibility of the use of excessive doses of the slowly acting protamine insulin by untrained persons (because of the lack of rapid action) or the accidental administration of the concentrated precipitate from a vial which has not been agitated makes essential a knowledge of the effects of hypoglycemia due to insulin shock. Insulin shock is being purposely used in the treatment of schizophrenia,1 and undesirable effects of this use are also important.

In all of the experiments recorded here protamine zinc insulin of a strength of 40 units per cubic centimeter was used. It was administered subcutaneously. During some experiments2 in which hyperalimentation was produced in albino rats by injections of protamine insulin, the first peculiar effects of hypoglycemia of

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