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December 1939


Arch Intern Med (Chic). 1939;64(6):1187-1196. doi:10.1001/archinte.1939.00190060056004

Infantilism has been frequently seen as a sequela of such chronic debilitating diseases as chronic renal disease,1 congenital and rheumatic heart disease, diabetes mellitus, avitaminosis, congenital syphilis, Addison's disease,2 Still's disease3 and congenital hemolytic icterus.4 Infantilism has been frequently reported in gastrointestinal disorders, especially in celiac disease and idiopathic steatorrhea.5 In one series of 15 cases of idiopathic steatorrhea, characteristic stigmas of infantilism appeared in 10.5a It has been found also in cases of chronic intestinal tuberculosis.2 I have seen 1 such case in the past year.

Despite the frequent mention of infantilism associated with the gastrointestinal disorders mentioned, it has not been reported in ulcerative colitis. Bargen,6 in summarizing the sequelae in 1,500 cases of ulcerative colitis, did not mention infantilism, nor did he, Jackman and Kerr7 speak of it in discussing another series of 871 cases, in 243 of which the patients were in the second and third

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