In the past few years a number of reports have appeared on the frequency and significance of azotemia following massive hemorrhage from the upper part of the digestive tract. The first of these communications were those of Sanguinetti1 who in 1933 and 1934 reported elevation of the urea nitrogen content of the blood in 9 cases of gastric or duodenal ulcer with hemorrhage. He assumed that this increase was due chiefly to absorption of products of decomposition of the blood in the intestinal tract, resulting in a state of intoxication which might prove fatal. He actually recommended cecostomy in order to remove this blood. He reported significant elevation of urea in the blood of 2 of 3 persons fed pig's blood.
In 1935, Cristiansen2 found elevation of the urea content of the blood and absence of urinary chlorides in 2 cases of bleeding gastric ulcer. He concluded that
SCHIFF L, STEVENS RJ. ELEVATION OF UREA NITROGEN CONTENT OF THE BLOOD FOLLOWING HEMATEMESIS OR MELENA. Arch Intern Med (Chic). 1939;64(6):1239–1251. doi:10.1001/archinte.1939.00190060108007
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