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Article
January 1940

EFFECT OF RENAL RETENTION OF VITAMIN C ON SATURATION TESTS: A FORMULA FOR COMPENSATION OF THIS FACTOR OF ERROR

Author Affiliations
NEW YORK
From the Department of Medicine of the New York Post-Graduate Medical School and Hospital.
Arch Intern Med (Chic). 1940;65(1):151-162. doi:10.1001/archinte.1940.00190070161011
Abstract

In 1933, Harris, Ray and Ward1 demonstrated the excretion of vitamin C in the urine and established a relationship between the excretion and the intake of this vitamin. Since that time, a number of chemical methods for the determination of the state of vitamin C nutrition in man have been presented. The determination of the twenty-four hour "resting level" of urinary excretion presented many technical disadvantages and was impractical in the study of ambulatory patients. The content of ascorbic acid in the fasting blood was observed to vary considerably with the recent dietary intake of vitamin C and gave only a rough index of the actual state of saturation.2 The test dose method, in which a given dose of ascorbic acid is administered and the output in the urine is used as an index of saturation, was found to have many advantages. Oral test doses of 300 to

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