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January 1940


Author Affiliations

Associate in Medicine, Harvard Medical School; Physician and Chief of Allergy Clinic, Massachusetts General Hospital. BOSTON

Arch Intern Med (Chic). 1940;65(1):185-212. doi:10.1001/archinte.1940.00190070195015

Last year I1 wrote: "Each year the papers written on allergy cover a wider territory." Now the situation is becoming even more complicated because it appears that certain symptoms, like asthma, may come from causes which are not allergy at all, though the clinical pictures seem to be quite the same as in the typical cases of allergy. "All is not allergy that wheezes," and, by the same token, sneezes and itches of various kinds which seem like allergy may not be due to allergy in the ordinary clinical sense. In a recent discussion of the relation between anaphylaxis and allergy, Dragstedt2 points out that whereas histamine, heparin and possibly other agents are liberated easily from sensitive cells as a result of the specific antigen-antibody reaction, the same substances may be released from normal cells which have been acted on by nonantigenic material. Evidently it is possible to