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The second edition of this well known manual does not differ in form or general arrangement from the first. Structural formulas for certain of the alkaloids have been changed to agree with present day views. Experiments with recently introduced drugs—evipal, pentobarbital, avertin with amylene hydrate and sulfanilamide—have been added. One of the most valuable features of both the first edition and the older manual of the senior author which preceded it is the table of doses suitable for laboratory animals. The new edition extends the list considerably and contains a tremendous amount of material that is elsewhere scattered through an extensive literature. Many of the doses have been confirmed in the laboratories of the authors. Few errors have been noted by this reviewer, the most serious one being the statement that digitalis is said to be assayed against ouabain in the eleventh revision of the United States Pharmacopeia. Ouabain has
Fundamentals of Experimental Pharmacology. Arch Intern Med (Chic). 1940;65(1):218. doi:10.1001/archinte.1940.00190070228020
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