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Article
February 1940

DISEASES OF METABOLISM AND NUTRITION: REVIEW OF CERTAIN RECENT CONTRIBUTIONS

Author Affiliations

Fellow in Medicine, the Mayo Foundation; ROCHESTER, MINN.; I. DISEASES OF METABOLISM By Dr. Wilder and Dr. Browne

From the Division of Medicine, the Mayo Clinic

Arch Intern Med (Chic). 1940;65(2):390-460. doi:10.1001/archinte.1940.00190080172011
Abstract

DIABETES MELLITUS 

Genesis.  —(a) Pituitary Gland and Carbohydrate Metabolism: In last year's review1 attention was directed to the significance of Young's production of permanent diabetes in dogs by repeated injections of crude extracts of anterior lobes of beef pituitaries for a long period. This work, together with the more significant literature that bears on the relation of the anterior lobe of the pituitary to carbohydrate metabolism, is reviewed by Young2 in a readable paper which he gave before the section of physiology at the annual meeting (1939) of the British Medical Association. A tentative general conclusion from experiments of Long, Russell, Bennett3 and others assigns to the secretion of the anterior lobe of the pituitary a depressive action on the oxidation of carbohydrate in the muscles and promotion of glycogen storage. Since the storage of glycogen can be promoted also by crystalline adreno cortical substances,4 the suggestion is made that

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