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March 1940


Author Affiliations

Fellow in Medicine, the Mayo Foundation ROCHESTER, MINN.

From the Division of Medicine, Section of Pathologic Anatomy and Section of Ophthalmology, the Mayo Clinic.

Arch Intern Med (Chic). 1940;65(3):545-586. doi:10.1001/archinte.1940.00190090082006

As a result of the original concepts of Volhard and Fahr,1 a malignant (bösartig) form of hypertension was separated from the general group in 1914. In 1924, however, Wagener and Keith2 described a syndrome of malignant hypertension and showed that this condition deserves the distinction of an entity, differing from chronic glomerulitis and benign hypertension on the basis of age incidence, a characteristic retinal picture, absence of anemia and frequent persistence of adequate renal function. This clinical concept of Wagener and Keith was further developed in investigations at the Mayo Clinic, the results of which were published in 1927,3 1928,4 1929,5 and 1931,6 and various pathologic studies of this disease have been reported from this institution by Cain,7 Morlock8 and Odel.9 None of these works included any comprehensive data regarding the brain. The purpose of the present study has been to survey the brain in cases of malignant hypertension, to