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Article
March 1940

UREA REABSORPTION AND RELATION BETWEEN CREATININE AND UREA CLEARANCE IN RENAL DISEASE

Author Affiliations

Associate Professor of Medicine, Rush Medical College, University of Chicago, and Chairman of the Department of Medicine, Cook County Graduate School of Medicine; CHICAGO

From the Cook County Graduate School of Medicine and the Cook County Hospital, Medical Service of Dr. Aaron Arkin.

Arch Intern Med (Chic). 1940;65(3):627-637. doi:10.1001/archinte.1940.00190090164010
Abstract

Richards1 has proved by examinations of the glomerular urine of the frog that urea is filtered through the glomerular loops.

The reabsorption of urea in the tubules was demonstrated by investigations based on the theory of Cushny and of Rehberg.2 Such substances as creatinine are filtered through the glomeruli but are not secreted or reabsorbed in the tubules. With this in mind, one is able to observe the pathway of other substances in the kidney.

The exogenous creatinine clearance method used by Rehberg for the determination of the filtration rate gives reliable results in the dog but not in man (Smith,3 Shannon4). In human subjects administration of creatinine causes an increase in the clearance as a result of secretion. Therefore, the inulin clearance method was employed in the calculation of the filtration rate (Shannon and Smith,5 Richards and his associates6). The endogenous creatinine clearance test probably does not involve this

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