The opportunity of following 11 instances of generalized Boeck's sarcoid over a period of several years has presented unusual chances to study the progress of the disease from the clinical, metabolic and etiologic viewpoints. The clinical aspects of the disease have been discussed by numerous authors,1 and Hunter2 has presented a full historical review. A great variety of syndromes which resemble sarcoid probably can be grouped together.3
Little has been written on the metabolic changes associated with the disease. The relation of calcium metabolism to the cystlike osseous lesions and of protein metabolism to the activity of the disease and to lesions in the liver have been discussed.4
Etiologic studies in the past have been directed chiefly toward the demonstration of tubercle bacilli in the lesions. The use of various animals, usually guinea pigs and to a less extent rabbits and pigeons, has given disappointing results. Smaller animals, such as
HARRELL GT. GENERALIZED SARCOIDOSIS OF BOECK: A CLINICAL REVIEW OF ELEVEN CASES, WITH STUDIES OF THE BLOOD AND THE ETIOLOGIC FACTORS. Arch Intern Med (Chic). 1940;65(5):1003–1034. doi:10.1001/archinte.1940.00190110132009
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