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Article
August 1940

INFECTIOUS DISEASESA REVIEW OF SIGNIFICANT PUBLICATIONS IN 1939-1940

Arch Intern Med (Chic). 1940;66(2):478-525. doi:10.1001/archinte.1940.00190140186010
Abstract

CHEMOTHERAPY  This year again, as in 1939, judging by the number of papers published on the subject, interest in chemotherapy dominates the field of infectious diseases. It is said that the incredible amount of 187 tons of sulfanilamide was used in the United States last year. Controlled experiments, too numerous to mention here, have in general confirmed earlier opinion as to the effectiveness or ineffectiveness of the sulfonamide derivatives in many diseases; in regard to others uncertainty still exists. In a recent review1 are listed and discussed numerous infections for which both practical and experimental studies in man and in animals have shown the drugs to be of value, of doubtful value and of no value. There have also been many papers with overly enthusiastic conclusions from observations in single cases or in an insufficient number of uncontrolled therapeutic tests. The Council on Pharmacy and Chemistry of the American

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