Experimental medicine usually receives its impetus from either clinical medicine or pathology. Thus, by the experimental production of lesions similar to those observed at autopsy, the reproduction of clinical symptoms, thought to be the result of organic changes, is often attempted. More rarely, perhaps, the investigator, without the definite support of clinical or pathologic observations, designs devices which when applied to the laboratory animal produce a definite complex of signs and symptoms. The results so obtained, however, cannot be applied to clinical medicine until a chance patient, dying from the same causes as the experimental animals, shows at postmortem examination conditions similar to those produced experimentally. The correlation with human pathology of results obtained from experimental work must await confirmation until by a "trick of nature" lesions identical to those experimentally produced are seen at postmortem examination.
Goldblatt's1 experimental production of permanent arterial hypertension by clamping the renal arteries
SAPHIR O, BALLINGER J. HYPERTENSION (GOLDBLATT) AND UNILATERAL MALIGNANT NEPHROSCLEROSIS. Arch Intern Med (Chic). 1940;66(3):541–560. doi:10.1001/archinte.1940.00190150012002
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