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September 1940

Provoked Alimentary Hyperglycemia: The Mechanism of the Tolerance Test.

Arch Intern Med (Chic). 1940;66(3):778-779. doi:10.1001/archinte.1940.00190150249015

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This work, as indicated by the title, represents the report of two investigations by Dr. Flint, who formerly was a professor of surgery at Yale University. The author's summaries contain the following material:

"Recapitulation.—From studies on the intermediate carbohydrate metabolism by the angiostomy method, observations were selected that correspond to the ordinary tolerance test. These throw much light upon provoked alimentary hyperglycemia. A criss-cross or shift of function between the liver and intestine takes place at the beginning and end of the tolerance reaction by which they exchange roles as yielding and retaining organs vis-á-vis the blood sugar. This shift occurs in the following sequence: upon the appearance of carbohydrates in the duodenum, absorption of sugar begins and its concentration in the intestine mounts until it passes the retention point and is then yielded to the portal radicals. The increanse in sugar concentration in the portal blood is the

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