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October 1940

La mielosi eritremica acuta (malattia di Guglielmo).

Arch Intern Med (Chic). 1940;66(4):1007. doi:10.1001/archinte.1940.00190160226012

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Hematologists in the United States are familiar with several syndromes in which large numbers of immature red cells are found in the blood and which appear to be definite dyscrasias of the erythropoietic system. Erythroblastosis foetalis and Cooley's erythroblastic anemia are cleancut entities, and the von Jaksch syndrome is less definite. Remarkable outpourings of nucleated erythrocytes and their precursors are observed in the "myeloid reaction"' incident to the metastasis of malignant growths to the marrow. This has been called "leukanemia." In Lederer's acute hemolytic anemia and in the hemolytic crises of familial hemolytic icterus many nucleated red cells may be found in the blood films. The Italian hematologists, however, seem to have a corner on a series of disorders described by them as erythremic myeloses. These disorders are classified as intergrades between erythroblastosis foetalis, which they designate as mielosis eritremica acutissima, and Cooley's anemia, which is called mielosis eritremica chronica

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