The action of adrenal cortical extract and the cause of crisis in Addison's disease are still not understood. The disturbance in sodium chloride metabolism was pointed out by Loeb1 when he observed the beneficial effect of the administration of these electrolytes. Later, Harrop and his co-workers2 showed that alteration of the sodium metabolism was the more important of the two. The importance of disturbed potassium metabolism in patients has been emphasized by Wilder and his associates3 and by Zwemer and Truszkowski.4 A study of the sodium, potassium and chloride excretion of 2 patients with Addison's disease showed several points of interest and prompted this report.
Both patients had undoubted moderately severe Addison's disease, and they had not received any previous treatment. The first was a youth 18 years of age and the second a woman 24 years of age. The first patient was studied for one hundred and fifty-nine consecutive
GREENE JA, JOHNSTON GW. ELECTROLYTE BALANCE DURING TREATMENT, CRISES AND SEVERE INFECTION IN CASES OF ADDISON'S DISEASE: ACTION OF ADRENAL CORTICAL EXTRACTS. Arch Intern Med (Chic). 1940;66(5):1052–1059. doi:https://doi.org/10.1001/archinte.1940.00190170043002
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