The use of acacia intravenously in the treatment of nephrotic edema was first employed in a systematic manner by Hartmann and his associates1 in 1933. They reported careful observations on 6 patients, all children, 5 of whom showed a satisfactory diuretic response after acacia was used (table 1). The daily dose amounted to 1 to 2 Gm. per kilogram of body weight in the majority of the cases. If necessary, administration was repeated at intervals of one day, two days or more. Of special interest is the observation of these authors that the renal lesion is likely to improve as diuresis is established, as was shown in their cases by a diminished amount of casts and a lessened degree of albuminuria. Improvement in renal function in 1 case was so great that a normal condition was completely reestablished, as was shown by absence of edema, normal urinary findings and
GOUDSMIT A, BINGER MW. ACACIA IN THE TREATMENT OF THE NEPHROTIC SYNDROME. Arch Intern Med (Chic). 1940;66(6):1252–1281. doi:10.1001/archinte.1940.00190180064006
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