Multiple primary malignant lesions of the large intestine have been reported occasionally. A number of factors have made this study seem timely: (1) the bearing that this syndrome may have on the problem of cancer in general; (2) the great importance that these multiple tumors may possess in respect to the prognosis for patients who have malignant lesions; (3) the relative paucity of attention that multiple malignant lesions of the large bowel have received, and (4) the relationship that polyps bear to the pathogenesis of malignant lesions of the large bowel.
Ewing,1 Hanlon2 and Orr3 stated the belief that multiple primary malignant lesions are merely coincidental occurrences. Warren and Gates4 have not expressed the same opinion, and a study of the cases reported in the present paper would draw us also away from such an opinion. Maud Slye5 was able to demonstrate that "in mice resistant by heredity, irritations and
SCHWEIGER LR, BARGEN JA. MULTIPLE PRIMARY MALIGNANT LESIONS OF THE LARGE BOWEL. Arch Intern Med (Chic). 1940;66(6):1331–1340. doi:10.1001/archinte.1940.00190180143010
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