[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.206.175.155. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1941

STAPHYLOCOCCIC BACTEREMIA: TREATMENT WITH SULFAPYRIDINE AND SULFATHIAZOLE

Arch Intern Med (Chic). 1941;67(1):25-35. doi:10.1001/archinte.1941.00200010035002
Abstract

Invasion of the blood stream by staphylococci often is attended with serious consequences. In a recent review, Mendell1 collected from the literature 279 cases of staphylococcic septicemia and added 35 of his own. He found the mortality rate in these 314 cases to be 77 per cent. This high death rate approximates the experience of most physicians, and because of it there have been many attempts to combat this type of infection with various specific therapeutic agents. It is now generally recognized that the high mortality rate is due in part to potent exotoxins elaborated by certain strains of staphylococci, which are disseminated through the blood and tissues. According to several reports,2 it would appear that the prompt administration of specific staphylococcus antitoxin is an effective method for treating this toxemia. However, this form of serotherapy has certain limitations.

Some highly invasive strains of staphylococci produce little or

×