The clinical signs and symptoms of myxedema are well known. However, prior to the last decade too little attention was directed to the biochemical processes of the disease. Hypothyroidism presumably results from a relative or an absolute deficiency of thyroid secretion. Since iodine comprises about 65 per cent of thyroxin, it would appear that further investigation of the metabolism of iodine as evidenced by the iodine levels of the blood and urine is indicated.
A characteristic alteration of the plasma cholesterol is found in patients with thyroid deficiency. This aspect has been investigated by several workers both before and after treatment with desiccated thyroid. The results of these investigations have shown that the level of the cholesterol in the blood is of value in the differential diagnosis of borderline cases of hypothyroidism.
This study had as its purpose the following determinations:
The level of the iodine in the blood
GREENE AM. IODINE AND CHOLESTEROL METABOLISMS IN PATIENTS WITH PRIMARY MYXEDEMA: A CLINICAL AND EXPERIMENTAL STUDY WITH A REPORT OF RESULTS OF TREATMENT. Arch Intern Med (Chic). 1941;67(1):114–128. doi:10.1001/archinte.1941.00200010124008
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