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Article
January 1941

HYPERACTIVE CARDIOINHIBITORY CAROTID SINUS REFLEX: A POSSIBLE AID IN THE DIAGNOSIS OF CORONARY DISEASE

Arch Intern Med (Chic). 1941;67(1):177-193. doi:10.1001/archinte.1941.00200010187011
Abstract

Within the past few years, since the publication of the comprehensive experimental work on the carotid sinus reflex by Hering1 and Heymans,2 there has been some application of the knowledge regarding this reflex to clinical medicine. The most important contributions are those of Weiss and Baker,3 Ferris, Capps and Weiss4 and Weiss, Capps and Ferris.5 They showed the relation of a hyperactive reflex to some of the unconscious and convulsive states in man.

That unconsciousness and convulsions might be induced in some persons by pressing on a carotid artery at its bifurcation has been known for hundreds of years. Ask-Upmark6 stated that the Assyrians used this method to dull pain during the rites of circumcision. The mechanism of its production, however, was not known until of late.

Before the hyperactive cardioinhibitory carotid sinus reflex is considered, the normal carotid sinus mechanism with its various reflex responses

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